States of exhaustion

doctrine of exhaustion

the exhaustion doctrine refers to one of the limits of intellectual property rights. once a product protected of ip right has been marketed either by the ip right owner or by others whit her consent, the ip right owner cannot prohibit the further commercialization (like the resale) of that product. thus , a critical element in determining that the owner of an ip right has exhausted her/his righ...

SnapShot: T Cell Exhaustion

The Generalized Method of Exhaustion

Abstract The method of exhaustion is generalized to a simple formula that can be used to integrate functions under very general conditions, provided that the integral exists. Both a geometric proof (following the usual procedure for the method of exhaustion) and an independent algebraic proof are provided. Applications provided as examples include use of the formula to generate new series for c...

NK Cell Exhaustion

Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustio...

Fitness without exhaustion.

stromal migration and engraftment of NOD/SCID mice. Blood. 2000;95(11):3289-3296. 5. Vagima Y, Avigdor A, Goichberg P, et al. MT1-MMP and RECK are involved in human CD34 progenitor cell retention, egress, and mobilization. J Clin Invest. 2009; 119(3):492-503. 6. Christopherson KWII, Hangoc G, Matel CR, et al. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science. 2004;30...